BONISTA CARTRIDGE VIAL

BONISTA Cartridge contains the active substance Teriparatide. It is a synthetic form of human Parathyroid Hormone (PTH) and belongs to a group of medicines known as Bone Formation Agents (Anabolic Osteoporosis Treatments). It is primarily used for the treatment of severe osteoporosis in postmenopausal women, men with osteoporosis, and patients with glucocorticoid-induced osteoporosis who are at high risk of fractures. Teriparatide stimulates new bone formation, increases bone density, and helps reduce the risk of fractures.

BONISTA Cartridge is designed for use with a compatible injection pen device and is administered as a daily subcutaneous injection under medical supervision.

Uses of BONISTA Cartridge

• Treatment of Severe Osteoporosis
• Postmenopausal Osteoporosis
• Osteoporosis in Men
• Glucocorticoid-Induced Osteoporosis
• Reduction of Fracture Risk
• Improvement of Bone Mineral Density (BMD)

Therapeutic Effects of BONISTA Cartridge

BONISTA Cartridge works by stimulating osteoblasts, the cells responsible for building new bone. Unlike many osteoporosis medicines that primarily slow bone loss, Teriparatide actively promotes new bone formation, increasing bone strength and reducing fracture risk.

Interaction of BONISTA Cartridge with Other Drugs

It is important to inform your healthcare professional about all medicines you are taking.

Notable interactions include:

• Digoxin: Increased risk of cardiac effects if calcium levels rise.
• Calcium Supplements: May increase blood calcium levels.
• Vitamin D Supplements: May require monitoring.
• Blood Pressure Medicines: May contribute to dizziness after injection.
• Diuretics: May affect calcium balance.

More Information about BONISTA Cartridge

• Keep out of reach of children.
• Store in a refrigerator at 2°C to 8°C.
• Do not freeze.
• Protect from direct sunlight.
• Store in the original package.
• Discard according to medical instructions after the recommended usage period.

How to Consume BONISTA Cartridge

BONISTA Cartridge is administered as a subcutaneous injection into the thigh or abdomen using a compatible pen device.

The usual dose is 20 mcg once daily, administered at the same time each day. Treatment duration is determined by your doctor and is often limited to a maximum recommended period.

Safety Advice for BONISTA Cartridge

Breast Feeding

Not Recommended

Consult your doctor before using this medicine while breastfeeding.

Alcohol

Caution

Alcohol may increase dizziness and may negatively affect bone health.

Liver

Caution

Use under medical supervision in patients with liver disorders.

Kidneys

Caution

Patients with severe kidney impairment require careful monitoring.

Driving

Caution

Dizziness or lightheadedness may occur shortly after injection. Avoid driving if affected.

Pregnancy

Not Recommended

BONISTA is generally not recommended during pregnancy.

Side Effects of BONISTA Cartridge

Side effects are unwanted symptoms caused by medicines. Although not everyone experiences them, some patients may develop side effects.

Common Side Effects of BONISTA Cartridge

• Nausea
• Dizziness
• Headache
• Leg cramps
• Joint pain
• Injection site reactions
• Fatigue

Serious Side Effects of BONISTA Cartridge

• High calcium levels (Hypercalcemia)
• Severe allergic reactions
• Persistent bone pain
• Kidney stone formation
• Severe dizziness or fainting
• Unusual bone disorders in high-risk patients

Word of Advice

Regular monitoring of calcium levels and bone health is recommended during BONISTA treatment. Ensure adequate calcium and vitamin D intake as advised by your doctor. Contact your healthcare provider immediately if you experience severe dizziness, persistent nausea, unusual bone pain, or symptoms of high calcium levels.

FAQs about BONISTA Cartridge

Q1. What is BONISTA Cartridge used for?

It is used to treat severe osteoporosis and reduce fracture risk in patients with weakened bones.

Q2. How does BONISTA work?

It stimulates new bone formation by activating bone-building cells called osteoblasts.

Q3. How is BONISTA administered?

It is given as a once-daily subcutaneous injection using a compatible pen device.

Q4. Can BONISTA reduce fracture risk?

Yes. It increases bone density and strength, helping lower the risk of fractures.

Q5. Does BONISTA require refrigeration?

Yes. The cartridge should be stored in a refrigerator between 2°C and 8°C and should not be frozen.

Fact Box of BONISTA Cartridge

Molecule Name: Teriparatide

Therapeutic Class: Osteoporosis Medicines

Pharmacological Class: Recombinant Human Parathyroid Hormone (PTH Analog)

Indications: Severe Osteoporosis, Postmenopausal Osteoporosis, Osteoporosis in Men, Glucocorticoid-Induced Osteoporosis, Fracture Risk Reduction.