BIONESP-40 PFS contains the active substance Darbepoetin Alfa 40mcg. It belongs to a group of medicines known as Erythropoiesis-Stimulating Agents (ESAs). It is primarily used for the treatment of anemia associated with Chronic Kidney Disease (CKD) and anemia caused by chemotherapy in cancer patients. It works by stimulating the bone marrow to produce more red blood cells, helping increase hemoglobin levels and reducing the need for blood transfusions.
Darbepoetin Alfa is a synthetic form of erythropoietin, a hormone naturally produced by the kidneys that regulates red blood cell production. Its longer duration of action allows less frequent dosing compared to conventional erythropoietin therapies.
BIONESP-40 PFS is supplied as a Prefilled Syringe (PFS) and should only be administered under the supervision of a qualified healthcare professional.
Uses of BIONESP-40 PFS
- Anemia due to Chronic Kidney Disease (CKD)
- Anemia in Dialysis Patients
- Chemotherapy-Induced Anemia
- Reduction in Blood Transfusion Requirements
- Management of Low Hemoglobin Levels in Eligible Patients
Therapeutic Effects of BIONESP-40 PFS
BIONESP-40 PFS stimulates erythropoietin receptors in the bone marrow, increasing the production of red blood cells. This improves oxygen delivery throughout the body and helps relieve symptoms such as fatigue, weakness, dizziness, and shortness of breath associated with anemia.
Interaction of BIONESP-40 PFS with Other Drugs
It is important to inform your healthcare professional about all medicines you are taking.
Notable interactions include:
- Thalidomide
- Lenalidomide
- Pomalidomide
- Warfarin
- Heparin
- Aspirin
- Clopidogrel
- Cyclosporine
- Tacrolimus
More Information about BIONESP-40 PFS
- Keep out of reach of children.
- Store in a refrigerator at 2°C–8°C.
- Do not freeze.
- Protect from light.
- Keep the syringe in its original packaging.
- Do not shake the syringe.
How to Consume BIONESP-40 PFS
BIONESP-40 PFS is administered as a subcutaneous (under the skin) or intravenous (IV) injection by a doctor or nurse.
The dosage and frequency are determined by hemoglobin levels, kidney function, body weight, and response to treatment. Regular blood tests are required to monitor therapy effectiveness.
Safety Advice for BIONESP-40 PFS
Breast Feeding
Consult Your Doctor
Information regarding breastfeeding is limited and medical advice is recommended.
Alcohol
Consult Your Doctor
Alcohol may worsen anemia-related symptoms and should be discussed with your doctor.
Liver
Caution
Patients with liver disease should use this medicine under close medical supervision.
Kidneys
Commonly Prescribed
Frequently used in patients with chronic kidney disease and dialysis-associated anemia.
Driving
Caution
May cause dizziness, fatigue, or drowsiness in some patients. Avoid driving if affected.
Pregnancy
Use Only on Medical Advice
Use during pregnancy only when clearly necessary and prescribed by a healthcare professional.
Side Effects of BIONESP-40 PFS
Common Side Effects of BIONESP-40 PFS
- High Blood Pressure
- Headache
- Rash
- Injection Site Pain
- Swelling of Hands or Feet
- Diarrhea
- Cough
- Fatigue
- Abdominal Pain
Serious Side Effects of BIONESP-40 PFS
- Blood Clots (Thromboembolism)
- Stroke
- Heart Attack
- Severe Hypertension
- Seizures
- Severe Allergic Reactions
- Pure Red Cell Aplasia (Rare)
Word of Advice
Regular monitoring of hemoglobin levels, blood pressure, iron status, and kidney function is essential during treatment with BIONESP-40 PFS. Patients should immediately report symptoms such as severe headache, vision changes, chest pain, breathing difficulties, swelling, or signs of blood clots. Iron, folic acid, and vitamin B12 levels may also need assessment to ensure optimal treatment response.
FAQs about BIONESP-40 PFS
Q1. What is BIONESP-40 PFS used for?
It is used to treat anemia caused by chronic kidney disease and chemotherapy.
Q2. How does BIONESP-40 work?
It stimulates the bone marrow to produce more red blood cells and increase hemoglobin levels.
Q3. How long does it take to work?
An increase in hemoglobin levels is usually seen within 2–6 weeks of treatment initiation.
Q4. Does BIONESP-40 require refrigeration?
Yes. It should be stored at 2°C–8°C and must not be frozen.
Q5. Can BIONESP-40 increase blood pressure?
Yes. High blood pressure is a known side effect and should be monitored regularly during treatment.
Fact Box of BIONESP-40 PFS
Molecule Name: Darbepoetin Alfa 40mcg
Therapeutic Class: Hematopoietic Agents
Pharmacological Class: Erythropoiesis-Stimulating Agent (ESA)
Indications: Anemia Associated with Chronic Kidney Disease (CKD), Dialysis-Related Anemia, Chemotherapy-Induced Anemia, Reduction of Blood Transfusion Requirements.
