DASANAT 50mg Tablet contains the active substance Dasatinib. It belongs to a group of medicines known as Tyrosine Kinase Inhibitors (TKIs). It is primarily indicated for the treatment of Philadelphia chromosome-positive Chronic Myeloid Leukemia (Ph+ CML) and Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL). Dasatinib works by blocking abnormal proteins that promote the growth and multiplication of cancer cells.
DASANAT 50mg Tablets are prescribed when leukemia cells contain the Philadelphia chromosome or when other leukemia treatments are not effective or tolerated. Regular monitoring by an oncologist or hematologist is essential throughout treatment.
Uses of DASANAT 50mg Tablets
- Treatment of Philadelphia chromosome-positive Chronic Myeloid Leukemia (Ph+ CML)
- Treatment of Philadelphia chromosome-positive Acute Lymphoblastic Leukemia (Ph+ ALL)
- Management of resistant or relapsed leukemia
- Long-term control of leukemia progression
- Targeted cancer therapy for specific genetic mutations
Therapeutic Effects of DASANAT 50mg Tablets
DASANAT 50mg Tablets work by inhibiting BCR-ABL tyrosine kinase, an abnormal protein produced by the Philadelphia chromosome. By blocking this protein, Dasatinib prevents cancer cells from growing and dividing, helping reduce the number of abnormal blood cells and slowing disease progression.
Interaction of DASANAT 50mg Tablets with Other Drugs
It is important to inform your healthcare professional about all medications you are taking, including prescription medicines, supplements, and herbal products.
Notable interactions include:
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Antacids containing aluminum, magnesium, or calcium: May reduce Dasatinib absorption.
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Amiodarone: Increased risk of heart rhythm abnormalities.
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Ketoconazole: May increase Dasatinib blood levels.
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Rifampicin: May reduce treatment effectiveness.
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Phenytoin and Carbamazepine: May lower Dasatinib levels.
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Other Chemotherapy Medicines: Increased risk of toxicity and bone marrow suppression.
More Information about DASANAT 50mg Tablets
- Keep out of reach of children and pets.
- Store below 30°C in a cool and dry place.
- Protect from moisture and direct sunlight.
- Keep tablets in their original packaging.
- Do not use expired medication.
How to Consume DASANAT 50mg Tablets
DASANAT 50mg Tablets are oral medications meant to be swallowed whole with a glass of water. They may be taken with or without food.
Do not crush, chew, or break the tablets. Take the medicine exactly as prescribed by your doctor and preferably at the same time every day. Avoid grapefruit or grapefruit juice during treatment as it may affect drug levels.
Safety Advice for DASANAT 50mg Tablets
Breast Feeding
Unsafe / Contraindicated
Breastfeeding should be avoided during treatment as Dasatinib may harm the infant.
Alcohol
Caution
Alcohol may worsen side effects such as dizziness, fatigue, and liver-related complications. Consult your doctor regarding alcohol consumption.
Liver
Caution
Patients with liver disease should use this medicine under close medical supervision.
Kidneys
Caution
Kidney function should be monitored during treatment, especially in patients with pre-existing kidney disorders.
Driving
Caution
DASANAT may cause dizziness, drowsiness, or blurred vision. Avoid driving if affected.
Pregnancy
Unsafe / Contraindicated
Dasatinib may cause serious fetal harm and should not be used during pregnancy. Effective contraception is recommended during treatment.
Side Effects of DASANAT 50mg Tablets
Side effects are unwanted symptoms caused by medicines. Although not everyone experiences them, some patients may develop side effects.
Common Side Effects of DASANAT 50mg Tablets
- Fatigue
- Nausea and vomiting
- Diarrhea
- Headache
- Skin rash
- Fever
- Muscle and joint pain
- Anemia
Serious Side Effects of DASANAT 50mg Tablets
- Pleural effusion (fluid around the lungs)
- Pulmonary hypertension
- Severe infections
- Severe bleeding
- Bone marrow suppression
- Low platelet count
- Heart-related complications
- Severe allergic reactions
Word of Advice
Regular blood tests are essential while taking DASANAT 50mg Tablets to monitor blood counts and treatment response. Contact your doctor immediately if you develop shortness of breath, chest pain, fever, unusual bleeding, severe fatigue, or signs of infection. Follow all scheduled appointments and never alter the prescribed dose without medical advice.
FAQs about DASANAT 50mg Tablets
Q1. What is DASANAT 50mg Tablet used for?
It is used to treat Philadelphia chromosome-positive Chronic Myeloid Leukemia (Ph+ CML) and Acute Lymphoblastic Leukemia (Ph+ ALL).
Q2. How does DASANAT work?
It blocks abnormal tyrosine kinase proteins, particularly BCR-ABL, which are responsible for cancer cell growth and multiplication.
Q3. Can DASANAT cause lung-related complications?
Yes. Pleural effusion and pulmonary hypertension are known serious side effects and require prompt medical attention.
Q4. What should I do if I miss a dose?
Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue your normal schedule. Do not take a double dose.
Q5. Can DASANAT increase infection risk?
Yes. The medicine may lower white blood cell counts, increasing susceptibility to infections. Seek medical attention if you develop fever or signs of infection.
Fact Box of DASANAT 50mg Tablets
Molecule Name: Dasatinib 50mg
Therapeutic Class: Antineoplastic Agents
Pharmacological Class: Tyrosine Kinase Inhibitors (TKIs)
Indications: Philadelphia Chromosome-Positive Chronic Myeloid Leukemia (Ph+ CML), Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia (Ph+ ALL), Resistant or Relapsed Leukemia Cases.
