ENBREL 25mg Injection contains the active substance Etanercept. It belongs to a group of medicines known as Tumor Necrosis Factor (TNF) Inhibitors. It is primarily used for the treatment of Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Plaque Psoriasis, and Juvenile Idiopathic Arthritis. Etanercept works by blocking TNF-alpha, a substance in the body that causes inflammation and joint damage.
ENBREL is supplied as a prefilled syringe for subcutaneous (under the skin) injection and is administered under the supervision of a healthcare professional or after proper training for self-administration.
Uses of ENBREL 25mg Injection
- Rheumatoid Arthritis (RA)
- Psoriatic Arthritis (PsA)
- Ankylosing Spondylitis (AS)
- Chronic Plaque Psoriasis
- Juvenile Idiopathic Arthritis (JIA)
- Juvenile Psoriatic Arthritis
Therapeutic Effects of ENBREL 25mg Injection
ENBREL works by binding to and neutralizing Tumor Necrosis Factor-alpha (TNF-α), a protein responsible for inflammation. By blocking TNF-α activity, the medicine helps reduce joint swelling, pain, stiffness, skin lesions, and prevents long-term damage to joints and tissues.
Interaction of ENBREL 25mg Injection with Other Drugs
It is important to inform your healthcare professional about all medicines you are taking.
Notable interactions include:
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Methotrexate: Commonly used together under medical supervision.
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Abatacept: Increased risk of serious infections.
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Anakinra: Combination generally not recommended.
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Live Vaccines: Should be avoided during treatment.
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Other Biologic Immunosuppressants: Increased risk of infections.
More Information about ENBREL 25mg Injection
- Keep out of reach of children.
- Store in a refrigerator at 2°C–8°C.
- Do not freeze.
- Protect from direct sunlight.
- Keep the prefilled syringe in the original carton until use.
How to Consume ENBREL 25mg Injection
ENBREL 25mg is administered as a subcutaneous injection into the thigh, abdomen, or upper arm. Injection sites should be rotated regularly to avoid skin irritation.
The medicine should only be administered according to your doctor's instructions. The prefilled syringe contains a single dose and should not be reused.
Safety Advice for ENBREL 25mg Injection
Breast Feeding
Caution
Use during breastfeeding only if recommended by your healthcare provider.
Alcohol
Caution
Alcohol may worsen liver-related complications, especially when used with other medicines such as methotrexate.
Liver
Caution
Patients with liver disease should use this medicine under close medical supervision.
Kidneys
Generally Safe
No major dose adjustment is usually required, but monitoring may be recommended.
Driving
Caution
ENBREL may cause dizziness or fatigue in some patients.
Pregnancy
Use Only on Medical Advice
Use during pregnancy only when clearly needed and prescribed by a healthcare professional.
Side Effects of ENBREL 25mg Injection
Side effects are unwanted symptoms caused by medicines. Although not everyone experiences them, some patients may develop side effects.
Common Side Effects of ENBREL 25mg Injection
- Injection site redness or pain
- Headache
- Mild fever
- Upper respiratory tract infections
- Skin rash
- Dizziness
Serious Side Effects of ENBREL 25mg Injection
- Serious infections (including tuberculosis)
- Severe allergic reactions
- Blood disorders
- Heart failure worsening
- Nervous system disorders
- Increased risk of certain cancers
- Hepatitis B reactivation
Word of Advice
Before starting ENBREL therapy, patients are usually screened for tuberculosis (TB) and other infections. Regular medical monitoring is important during treatment. Contact your doctor immediately if you develop persistent fever, cough, unexplained weight loss, severe fatigue, or signs of infection. Avoid live vaccines while receiving ENBREL.
FAQs about ENBREL 25mg Injection
Q1. What is ENBREL 25mg Injection used for?
It is used to treat autoimmune inflammatory conditions such as Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, and Plaque Psoriasis.
Q2. How does ENBREL work?
It blocks TNF-alpha, a protein that causes inflammation and tissue damage in autoimmune diseases.
Q3. Can ENBREL increase the risk of infections?
Yes. Since it suppresses part of the immune system, it may increase susceptibility to infections.
Q4. How is ENBREL administered?
It is given as a subcutaneous injection under the skin using a prefilled syringe.
Q5. Do I need regular monitoring while using ENBREL?
Yes. Regular check-ups and laboratory tests are recommended to monitor for infections and treatment-related side effects.
Fact Box of ENBREL 25mg Injection
Molecule Name: Etanercept 25mg
Therapeutic Class: Immunosuppressants
Pharmacological Class: TNF-Alpha Inhibitors
Indications: Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Plaque Psoriasis, Juvenile Idiopathic Arthritis, Autoimmune Inflammatory Disorders.
