BEVACIREL 400mg Injection contains the active substance Bevacizumab 400mg/16ml. It belongs to a group of medicines known as Monoclonal Antibodies (VEGF Inhibitors). It is primarily used for the treatment of various cancers, including colorectal cancer, non-small cell lung cancer, kidney cancer, ovarian cancer, cervical cancer, and glioblastoma (brain tumor). It works by preventing the formation of new blood vessels that supply nutrients to tumors, thereby slowing or stopping cancer growth.
BEVACIREL is a biosimilar form of Bevacizumab manufactured by Reliance Life Sciences and is administered as an intravenous infusion under the supervision of an oncology specialist.
Uses of BEVACIREL 400mg Injection
- Metastatic Colorectal Cancer
- Non-Small Cell Lung Cancer (NSCLC)
- Kidney Cancer (Renal Cell Carcinoma)
- Ovarian Cancer
- Cervical Cancer
- Glioblastoma (Brain Tumor)
- Recurrent or Metastatic Solid Tumors (in combination with chemotherapy)
Therapeutic Effects of BEVACIREL 400mg Injection
BEVACIREL works by targeting Vascular Endothelial Growth Factor (VEGF), a protein responsible for the formation of new blood vessels. By blocking VEGF, the medicine cuts off the blood supply to cancer cells, slowing tumor growth and reducing the spread of cancer.
Interaction of BEVACIREL 400mg Injection with Other Drugs
It is important to inform your healthcare professional about all medicines you are taking.
Notable interactions include:
- Chemotherapy Medicines
- Blood Thinners (Warfarin, Ticagrelor)
- NSAIDs (Diclofenac, Etoricoxib)
- Anti-Cancer Monoclonal Antibodies
- Live Vaccines
- Medicines that increase bleeding risk
More Information about BEVACIREL 400mg Injection
- Keep out of reach of children.
- Store in a refrigerator at 2°C–8°C.
- Do not freeze.
- Protect from direct sunlight.
- Administer only under medical supervision.
- For intravenous infusion use only.
How to Consume BEVACIREL 400mg Injection
BEVACIREL 400mg Injection is administered as an intravenous (IV) infusion by a qualified healthcare professional.
The dosage and treatment schedule depend on the type of cancer, body weight, and response to therapy. It is commonly given in combination with chemotherapy medicines.
Safety Advice for BEVACIREL 400mg Injection
Breast Feeding
Not Recommended
Breastfeeding should be avoided during treatment and for a period after therapy completion as advised by your doctor.
Alcohol
Consult Your Doctor
The interaction with alcohol is not well established. Consult your healthcare provider.
Liver
Generally Safe Under Medical Supervision
Dose adjustment is usually not required, but monitoring may be advised.
Kidneys
Generally Safe Under Medical Supervision
No significant dose adjustment is generally required.
Driving
Caution
May cause dizziness, weakness, or fainting. Avoid driving if affected.
Pregnancy
Contraindicated
May cause serious harm to the unborn baby and should not be used during pregnancy. Effective contraception is recommended during treatment.
Side Effects of BEVACIREL 400mg Injection
Side effects are unwanted symptoms caused by medicines. Although not everyone experiences them, some patients may develop side effects.
Common Side Effects of BEVACIREL 400mg Injection
- High Blood Pressure
- Headache
- Nosebleeds
- Protein in Urine
- Fatigue
- Taste Changes
- Back Pain
- Dry Skin
- Rhinitis (Nasal Inflammation)
Serious Side Effects of BEVACIREL 400mg Injection
- Severe Bleeding
- Gastrointestinal Perforation
- Blood Clots
- Delayed Wound Healing
- Severe Hypertension
- Infusion Reactions
- Heart Problems
- Severe Allergic Reactions
Word of Advice
Patients receiving BEVACIREL should undergo regular monitoring of blood pressure, urine protein levels, kidney function, and overall treatment response. Inform your doctor before any planned surgery because this medicine can delay wound healing. Seek immediate medical attention if you notice unusual bleeding, severe abdominal pain, chest pain, breathing difficulties, or sudden neurological symptoms.
FAQs about BEVACIREL 400mg Injection
Q1. What is BEVACIREL 400mg Injection used for?
It is used to treat several cancers, including colorectal cancer, lung cancer, kidney cancer, ovarian cancer, cervical cancer, and brain tumors.
Q2. How does BEVACIREL work?
It blocks VEGF, preventing tumors from developing new blood vessels needed for growth.
Q3. Is BEVACIREL chemotherapy?
No. It is a targeted cancer therapy (monoclonal antibody) often used alongside chemotherapy.
Q4. How is BEVACIREL administered?
It is given as an intravenous infusion by a healthcare professional.
Q5. Can BEVACIREL increase bleeding risk?
Yes. Patients should immediately report unusual bleeding, blood in stools, or persistent nosebleeds.
Fact Box of BEVACIREL 400mg Injection
Molecule Name: Bevacizumab 400mg/16ml
Therapeutic Class: Anti-Cancer Medicines
Pharmacological Class: Monoclonal Antibody (VEGF Inhibitor)
Indications: Metastatic Colorectal Cancer, Non-Small Cell Lung Cancer, Kidney Cancer, Ovarian Cancer, Cervical Cancer, Glioblastoma, Advanced Solid Tumors.
