DEFRIJET 500mg Tablet contains the active substance Deferasirox. It belongs to a group of medicines known as Iron Chelating Agents. It is primarily used for the treatment of chronic iron overload caused by frequent blood transfusions in conditions such as Thalassemia, Sickle Cell Anemia, Myelodysplastic Syndromes, and other chronic anemias. It may also be used in patients with non-transfusion-dependent thalassemia who have excess iron accumulation.
Deferasirox works by binding excess iron in the body and removing it through the stool, helping prevent iron-related damage to vital organs such as the liver, heart, and endocrine glands.
DEFRIJET 500mg Tablets should only be used under the supervision of a healthcare professional with regular monitoring of iron levels and organ function.
Uses of DEFRIJET 500mg Tablets
- Chronic Iron Overload due to repeated blood transfusions
- Thalassemia-associated iron overload
- Sickle Cell Disease with iron overload
- Myelodysplastic Syndrome (MDS) with iron accumulation
- Non-Transfusion-Dependent Thalassemia (NTDT)
- Prevention of iron-induced organ damage
Therapeutic Effects of DEFRIJET 500mg Tablets
DEFRIJET 500mg Tablets work by selectively binding excess iron present in the bloodstream and tissues. The iron-chelator complex formed is eliminated from the body, reducing iron burden and helping protect organs from long-term damage caused by iron accumulation.
Interaction of DEFRIJET 500mg Tablets with Other Drugs
It is important to inform your healthcare professional about all medicines you are taking.
Notable interactions include:
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Aluminum-containing antacids: May interfere with treatment.
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Theophylline: Increased risk of adverse effects.
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Repaglinide: May increase blood sugar-related complications.
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Blood Thinners: Increased bleeding risk.
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Other Iron Chelators: Should not be used together unless prescribed.
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Nephrotoxic Medicines: Increased risk of kidney damage.
More Information about DEFRIJET 500mg Tablets
- Keep out of reach of children.
- Store below 30°C in a cool and dry place.
- Protect from moisture and direct sunlight.
- Keep tablets in their original packaging.
- Do not use expired medication.
How to Consume DEFRIJET 500mg Tablets
DEFRIJET 500mg Tablets are oral medications taken exactly as prescribed by your doctor.
The tablet is generally taken on an empty stomach at least 30 minutes before meals. Take it at the same time every day for maximum benefit. Dosage is determined based on body weight, ferritin levels, and treatment response.
Safety Advice for DEFRIJET 500mg Tablets
Breast Feeding
Caution
Use during breastfeeding only if recommended by your doctor.
Alcohol
Avoid or Limit
Alcohol may increase the risk of liver-related side effects.
Liver
Caution
Patients with liver disease require close monitoring and dose adjustments if necessary.
Kidneys
Caution
Kidney function should be monitored regularly as DEFRIJET may cause kidney-related complications.
Driving
Caution
This medicine may cause dizziness. Avoid driving or operating machinery if affected.
Pregnancy
Use Only on Medical Advice
Use during pregnancy only if clearly needed and prescribed by a healthcare professional.
Side Effects of DEFRIJET 500mg Tablets
Side effects are unwanted symptoms caused by medicines. Although not everyone experiences them, some patients may develop side effects.
Common Side Effects of DEFRIJET 500mg Tablets
- Nausea
- Vomiting
- Diarrhea
- Abdominal pain
- Headache
- Skin rash
- Constipation
- Increased serum creatinine levels
Serious Side Effects of DEFRIJET 500mg Tablets
- Kidney failure
- Liver dysfunction
- Gastrointestinal bleeding
- Hearing impairment
- Vision problems
- Severe allergic reactions
- Severe blood disorders
Word of Advice
Patients taking DEFRIJET 500mg Tablets require regular monitoring of serum ferritin levels, kidney function, liver function, hearing, and vision. Seek immediate medical attention if you experience reduced urine output, yellowing of the eyes or skin, black stools, vomiting blood, hearing loss, or visual disturbances. Regular follow-up helps ensure safe and effective treatment.
FAQs about DEFRIJET 500mg Tablets
Q1. What is DEFRIJET 500mg Tablet used for?
It is used to treat chronic iron overload caused by repeated blood transfusions and certain forms of thalassemia.
Q2. How does DEFRIJET work?
It binds excess iron in the body and helps eliminate it through the stool.
Q3. When should DEFRIJET be taken?
It is usually taken on an empty stomach at least 30 minutes before meals.
Q4. Can DEFRIJET affect the kidneys?
Yes. Kidney function should be monitored regularly during treatment.
Q5. Why are regular blood tests necessary?
Blood tests help monitor iron levels and detect any kidney or liver-related complications early.
Fact Box of DEFRIJET 500mg Tablets
Molecule Name: Deferasirox 500mg
Therapeutic Class: Iron Chelating Agents
Pharmacological Class: Oral Iron Chelator
Indications: Chronic Iron Overload, Thalassemia-Associated Iron Overload, Sickle Cell Disease, Non-Transfusion-Dependent Thalassemia (NTDT), Prevention of Iron-Induced Organ Damage.
